During my six years as an immunology grad student, HIV research papers that had the words ‘T cells,’ ‘antibodies’ and ‘vaccine’ in them always sat on or near the top of my must-read pile. I read those papers with enthusiasm even though, by the time I got to figure 4 or 5 in the ‘results’ section, their gist seemed to carry a whiff of discouragement. When I graduated, my ardor cooled a bit. The jobs that I stumbled into required my antennae to be retuned to catch news from all fields of biomedical research. But I still kept au courant with the topic via review papers and news summaries, if not primary articles.
Then I started to read about HIV researchers saying that maybe it wasn’t realistic to hope for a sterilizing cure – the kind you get when the virus is completely wiped out in each and every infected cell of a person. Researchers had figured out how to treat HIV patients with combinations of anti-HIV drugs so that viral loads were kept low and CD4 T cell counts relatively high. Patients who maintain a certain ratio of CD4 T cells (the immune cells that the virus attacks and kills off) to viral load have been able to live symptom-free longer and with relatively small toxicity-induced organ damage. So maybe, these researchers said, the anti-HIV drug combos, which were getting cheaper and cheaper, were as good as it was ever going to get.
And then in 2007, Merck’s experimental HIV vaccine, which was then the research community’s big hope, flopped in a hugely disappointing trial. After that, I really couldn’t dredge up the enthusiasm to follow the field.
This summer, though, HIV/AIDS news seems to have inexplicably become impossible to ignore. A bunch of “Can-we-cure-AIDS?” type of stories have started to appear in many major science and popular news outlets. (Or maybe this sudden reappearance is not so inexplicable. The 18th International AIDS Conference starts in Vienna today and maybe some scientist somewhere has good news that was selectively leaked and that will soon be known to all. One can hope.)
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